Knowledge Synthesis and Application Unit

The Appraisal of Guidelines for Research and Evaluation (AGREE) Instrument evaluates the process of practice guideline development and the quality of reporting. To improve the rigor and timeliness of practice guidelines, many have taken on a living approach, which the current iteration of the instrument (AGREE II) does not evaluate. This project aims to update the AGREE tool so that it can be used to properly evaluate the quality of living practice guidelines.

Given the continued evolution of the pandemic, updated information is crucial for guiding policy decisions and prioritizing research efforts. This living review evaluates the effectiveness of WHO-approved COVID-19 vaccines (Pfizer–BioNTech, Moderna, Oxford–AstraZeneca, and Janssen) in protecting against Long Covid outcomes caused by variants of concern in adults.